发明授权
EP1830889B1 CONJUGATES OF INSULIN-LIKE GROWTH FACTOR-1 (IGF-1) AND POLY(ETHYLENE GLYCOL)
有权
胰岛素样生长因子-1（IGF-1）和聚（乙二醇）的共轭物
- 专利标题： CONJUGATES OF INSULIN-LIKE GROWTH FACTOR-1 (IGF-1) AND POLY(ETHYLENE GLYCOL)
- 专利标题（中）： 胰岛素样生长因子-1（IGF-1）和聚（乙二醇）的共轭物
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申请号： EP05849990.6申请日： 2005-12-21
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公开(公告)号： EP1830889B1公开(公告)日： 2017-05-17
- 发明人: AMREIN, Beat , FOSER, Stefan , LANG, Kurt , METZGER, Friedrich , REGULA, Jörg , SCHAUBMAR, Andreas , HESSE, Friederike , KUENKELE, Klaus-Peter , LANZENDOERFER,Martin
- 申请人： F. Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4002 Basel CH
- 专利权人： F. Hoffmann-La Roche AG
- 当前专利权人： F. Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4002 Basel CH
- 代理机构： Braun, Axel
- 优先权： EP04030415 20041222
- 国际公布： WO2006066891 20060629
- 主分类号： A61K47/60
- IPC分类号： A61K47/60 ; A61P25/28
摘要：
A conjugate consisting of an insulin-like growth factor-1 (IGF-I) variant and one or two poly(ethylene glycol) group(s), characterized in that said IGF-I variant has an amino acid alteration at up to three amino acid positions 27, 37, 65, 68 of the wild-type IGF-I amino acid sequence so that one or two of said amino acids is/are lysine and amino acid 27 is a polar aminio acid but not lysine, is conjugated via the primary amino group(s) of said lysine(s) and said poly(ethylene glycol) group(s) have an overall molecular weight of from 20 to 100 kDa is disclosed. This conjugate is useful for the treatment of neurodegenerative disorders like Alzheimer's Disease.
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