发明公开
- 专利标题: OPTICAL RESOLUTION METHOD OF AMLODIPINE
- 专利标题(中): 方法氨氯地平的光隔
-
申请号: EP05821317申请日: 2005-12-02
-
公开(公告)号: EP1831166A4公开(公告)日: 2009-09-02
- 发明人: KIM JAE-SUN , KIM NAM HO , LEE NAM KYU
- 申请人: SK CHEMICALS CO LTD
- 专利权人: SK CHEMICALS CO LTD
- 当前专利权人: SK CHEMICALS CO LTD
- 优先权: KR20040100613 2004-12-02; KR20040105612 2004-12-14
- 主分类号: C07D211/90
- IPC分类号: C07D211/90
摘要:
The present invention relates to a method for optical resolution of amlodipines by using isopropanol solvent and optically active O,O'-dibenzoyl tartaric acid as chiral reagent., More particularly, the present invention relates to a method comprising (a) obtaining (R)- or (S)-amlodipine dibenzoyl tartrate salt or solvate thereof by reacting (R,S)-amlodipines with optically active O,O'-dibenzoyl tartaric acid in isopropanol solvent, and (b) treating the (R)- or (S)-amlodipine salt with a base, thus obtaining optically active amlodipine.
信息查询