发明公开
EP1832281A1 Process for producing a solid dispersion of an active ingredient
审中-公开
Verfahren zur Herstellung einer Feststoffdispersion eines aktiven Wirkstoffes
- 专利标题： Process for producing a solid dispersion of an active ingredient
- 专利标题（中）： Verfahren zur Herstellung einer Feststoffdispersion eines aktiven Wirkstoffes
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申请号： EP06004999.6申请日： 2006-03-10
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公开(公告)号： EP1832281A1公开(公告)日： 2007-09-12
- 发明人: Kessler, Thomas , Breitenbach, Jörg , Schmidt, Christoph , Degenhardt, Matthias , Rosenberg, Jörg , Krull, Harald
- 申请人： Abbott GmbH & Co. KG
- 申请人地址： Max-Planck-Ring 2 65205 Wiesbaden DE
- 专利权人： Abbott GmbH & Co. KG
- 当前专利权人： Abbott GmbH & Co. KG
- 当前专利权人地址： Max-Planck-Ring 2 65205 Wiesbaden DE
- 代理机构： Reitstötter - Kinzebach
- 主分类号： A61K9/20
- IPC分类号： A61K9/20 ; B29C47/00 ; B29C47/60 ; B29C31/00 ; B29C47/10 ; B29C47/38 ; B29C47/40 ; B29C47/64 ; B29C47/76 ; B29C47/82 ; B29C35/02
摘要：
A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element (figure 2).
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