发明授权
EP1842920B2 Cells coexpressing vitamin K reductase and vitamin K dependent protein and use thereof to improve the productivity of said vitamin K dependent protein
有权
共表达维生素K还原酶和维生素K依赖性蛋白质的细胞及其用于提高所述维生素K依赖性蛋白质的生产力的用途
- 专利标题： Cells coexpressing vitamin K reductase and vitamin K dependent protein and use thereof to improve the productivity of said vitamin K dependent protein
- 专利标题（中）： 共表达维生素K还原酶和维生素K依赖性蛋白质的细胞及其用于提高所述维生素K依赖性蛋白质的生产力的用途
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申请号： EP07109353.8申请日： 2004-09-23
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公开(公告)号： EP1842920B2公开(公告)日： 2017-06-21
- 发明人: Stafford, Darrel , Li, Tao
- 申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
- 申请人地址： 308 Bynum Hall, Campus Box 4105 Chapel Hill, NC 27599-4105 US
- 专利权人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
- 当前专利权人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
- 当前专利权人地址： 308 Bynum Hall, Campus Box 4105 Chapel Hill, NC 27599-4105 US
- 代理机构： Gill Jennings & Every LLP
- 优先权： US505527P 20030923
- 主分类号： C12N15/68
- IPC分类号： C12N15/68 ; C12N9/04
摘要：
The present invention provides a host cell comprising a heterologous nucleic acid encoding a vitamin K epoxide reductase (VKOR) and a nucleic acid encoding a vitamin K dependent protein, wherein the nucleic acids encoding both the VKOR and Vitamin K dependent protein are expressed in said host cell. The invention also provides methods for improving the productivity of vitamin K dependent protein expression in a host cell.
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