The present invention provides a manufacturing method of three-dimensional cross-linked foam for uppers of shoes that comprises preparing plural foaming materials having a planar shape with the cross-linked foaming suppressed; forming at least one interfacing pattern including a main interfacing pattern on at least one of the foaming materials; cross-linked foaming the foaming material to obtain a planar cross-linked foam having at least one inner cavity structure including a main inner cavity structure, the main inner cavity structure formed by the main interfacing pattern; disposing the planar cross-linked foam in a cavity of a molding die, the cavity having a shape corresponding to a last; and blow molding a covering portion of the main inner cavity structure into a shape corresponding to the cavity of the molding die by closing the molding die and injecting fluid into the main inner cavity structure.