A dispenser bottle and associated closure has a sifter disposed in the neck thereof, either in the form of castellated vents formed in the interior peripheral edge of the neck or a separate sifter element. A rotatable cap is positioned over the sifter. The cap has holes that align with the vents or holes in the sifter to dispense material from the bottle. A removable lock ring is removeably conjoined to the cap to evidence tampering. One embodiment employs a squeeze tab that is depressed to open the bottle thereby increasing the dexterity required for opening. Another embodiment employs a rotatable sifter that must be held by one hand while the cap is held and rotated relative to the sifter by the other hand. A detent provides resistance to opening.