发明公开
EP1856056A1 PHENOXY BENZAMIDE COMPOUNDS WITH UTILITY IN THE TREATMENT OF TYPE 2 DIABETES AND OBESITY
审中-公开
PHENOXYBENZAMIDVERBINDUNGEN参与了2型糖尿病和利益肥胖的治疗方法有
- 专利标题: PHENOXY BENZAMIDE COMPOUNDS WITH UTILITY IN THE TREATMENT OF TYPE 2 DIABETES AND OBESITY
- 专利标题(中): PHENOXYBENZAMIDVERBINDUNGEN参与了2型糖尿病和利益肥胖的治疗方法有
-
申请号: EP05791490.5申请日: 2005-10-11
-
公开(公告)号: EP1856056A1公开(公告)日: 2007-11-21
- 发明人: JOHNSTONE, Craig , MCKERRECHER, Darren , PIKE, Kurt Gordon , WARING, Michael James
- 申请人: AstraZeneca AB
- 申请人地址: 151 85 Södertälje SE
- 专利权人: AstraZeneca AB
- 当前专利权人: AstraZeneca AB
- 当前专利权人地址: 151 85 Södertälje SE
- 优先权: GB0423043 20041016
- 国际公布: WO2006040528 20060420
- 主分类号: C07D231/40
- IPC分类号: C07D231/40 ; C07D213/80 ; C07D403/12
摘要:
Compounds of Formula: (I); wherein: R1 is methoxymethyl; R2 is selected from -C(O)NR4R5, SO2NR4R5, S(O)pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linked optionally substituted heterocyclyl ring; R3 is selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; R4 is selected from for example hydrogen, optionally substituted (1-4C)alkyl and HET-2; R5 is hydrogen or (1-4C)alkyl; or R4 and R5 together with the nitrogen atom to which they are attached may form a heterocyclyl ring system as defined by HET-3; HET-3 is for example an optionally substituted N-linked, 4, 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, pro drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.
信息查询