A multi-clip device for hemostasis includes an introducing tube (outer sheath) insertable into a body cavity. An operating wire is disposed within the introducing tube and is advanceable and retractable within the introducing tube. A plurality of detachable clips are arranged in a serial fashion within the introducing tube. Each clip has an engagement portion at the proximal end thereof and a plurality of arms extending towards the distal end thereof. The distal end of the operating wire engages the engagement portion of the proximal most clip, and the arms of the proximal most clip engage the engagement portion of the adjacent distally located clip. An expandable collar is slidably disposed about the arms of the clip and is configured such that when the collar is moved distally over the arms it closes and holds them in a closed position. The expandable collar has an expanding portion that is engaged by the distal end of t introducing tube so that the introducing tube can be used to advance the collar distally relative to the clip.