发明公开
EP1863799A1 CGRP-ANTAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL
审中-公开
CGRP拮抗剂，它们的生产方法及其作为药物
- 专利标题： CGRP-ANTAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL
- 专利标题（英）： Cgrp-antagonists, process for their preparation as well as their use as medicaments
- 专利标题（中）： CGRP拮抗剂，它们的生产方法及其作为药物
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申请号： EP06723538.2申请日： 2006-03-18
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公开(公告)号： EP1863799A1公开(公告)日： 2007-12-12
- 发明人: MUELLER, Stephan, Georg , RUDOLF, Klaus , LUSTENBERGER, Philipp , STENKAMP, Dirk , SANTAGOSTINO, Marco , PALEARI, Fabio , DOODS, Henri , ARNDT, Kirsten , SCHAENZLE, Gerhard
- 申请人： Boehringer Ingelheim International GmbH , Boehringer Ingelheim Pharma GmbH & Co. KG
- 申请人地址： Binger Strasse 173 55216 Ingelheim am Rhein DE
- 专利权人： Boehringer Ingelheim International GmbH,Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人： Boehringer Ingelheim International GmbH,Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人地址： Binger Strasse 173 55216 Ingelheim am Rhein DE
- 代理机构： Hammann, Heinz
- 优先权： PCT/EP2005/003094 20050323; PCT/EP2005/004104 20050418; EP05021283 20050929
- 国际公布： WO2006100009 20060928
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; C07D413/14 ; C07D405/14
摘要：
The invention relates to CGRP antagonists of general formula (I) in which: R1, R2, R3, R4 and X are defined as in Claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts as well as the hydrates of the salts, in particular, their physiologically compatible salts with inorganic or organic acids and bases, and those compounds of general formula (I) in which one or more hydrogen atoms are replaced by deuterium. The invention also relates to medicaments containing these compounds, the use thereof, and to methods for producing them.
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