发明公开
- 专利标题: PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA
- 专利标题(中): 吡啶PKC抑制剂THETA
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申请号: EP06748747.0申请日: 2006-03-27
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公开(公告)号: EP1866286A1公开(公告)日: 2007-12-19
- 发明人: TSCHANTZ, Matt Aaron , LEMIEUX, Rene Marc , KIM, Jin Mi , BRUNETTE, Steven Richard
- 申请人: Boehringer Ingelheim Pharma GmbH & Co. KG , BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 申请人地址: Binger Strasse 173 55216 Ingelheim DE
- 专利权人: Boehringer Ingelheim Pharma GmbH & Co. KG,BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人: Boehringer Ingelheim Pharma GmbH & Co. KG,BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人地址: Binger Strasse 173 55216 Ingelheim DE
- 代理机构: Hammann, Heinz
- 优先权: US665748P 20050328
- 国际公布: WO2006105023 20061005
- 主分类号: C07D213/74
- IPC分类号: C07D213/74 ; C07D401/12 ; C07D213/85 ; A61K31/44 ; A61K31/4523 ; A61P3/00 ; A61P37/00 ; A61P29/00
摘要:
Disclosed are novel compounds of formula (I) wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
公开/授权文献
- EP1866286B1 PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA 公开/授权日:2009-05-27
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