发明授权
EP1869048B8 METHOD FOR PRODUCING ALPHA FORM CRYSTALS OF SAPROPTERIN HYDROCHLORIDE
有权
用于生产晶体的α形态SAPROPTERINHYDROCHLORID
- 专利标题： METHOD FOR PRODUCING ALPHA FORM CRYSTALS OF SAPROPTERIN HYDROCHLORIDE
- 专利标题（中）： 用于生产晶体的α形态SAPROPTERINHYDROCHLORID
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申请号： EP06732122.4申请日： 2006-04-13
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公开(公告)号： EP1869048B8公开(公告)日： 2009-04-15
- 发明人: HOTODA, Katsumi , KIYONO, Hiroomi , TAZAWA, Shinnosuke
- 申请人： Shiratori Pharmaceutical Co., Ltd. , Asubio Pharma Co., Ltd.
- 申请人地址： 6-11-24, Tsudanuma Narashino-shi Chiba 275-0016 JP
- 专利权人： Shiratori Pharmaceutical Co., Ltd.,Asubio Pharma Co., Ltd.
- 当前专利权人： Shiratori Pharmaceutical Co., Ltd.,Asubio Pharma Co., Ltd.
- 当前专利权人地址： 6-11-24, Tsudanuma Narashino-shi Chiba 275-0016 JP
- 代理机构： Blodig, Wolfgang
- 优先权： JP2005116687 20050414
- 国际公布： WO2006112495 20061026
- 主分类号： C07D475/04
- IPC分类号： C07D475/04
摘要：
ABSTRACT A method for selectively producing stable alpha form crystals of sapropterin hydrochloride is provided. In this method, the alpha form crystal of sapropterin hydrochloride is produced by dissolving sapropterin hydrochloride with hydrochloric acid at a concentration of not less than 4 mol/L at not less than 70degrees C; adding heated ethanol to the solution; and cooling the solution at a cooling rate of not faster than 3degrees C/min to a temperature of 40 to 55degrees C to precipitate the crystals.
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