发明公开
- 专利标题： AMINOACID CONJUGATES OF BETA-LAPACHONE FOR TUMOR TARGETING
- 专利标题（中）： BETA拉帕醌和氨基用于肿瘤靶向结合物
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申请号： EP05785192.5申请日： 2005-08-11
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公开(公告)号： EP1877097A2公开(公告)日： 2008-01-16
- 发明人: ASHWELL, Mark , TANDON, Manish , LAPIERRE, Jean-Marc , LIU, Yanbin
- 申请人： ARQULE, INC.
- 申请人地址： 19 Presidential Way Woburn, MA 01801-5140 US
- 专利权人： ARQULE, INC.
- 当前专利权人： ARQULE, INC.
- 当前专利权人地址： 19 Presidential Way Woburn, MA 01801-5140 US
- 代理机构： Nohlen, Martin
- 优先权： US600373P 20040811
- 国际公布： WO2006020719 20060223
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; C07D311/92 ; A61P35/00
摘要：
The present invention relates to quinone prodrug compositions and therapeutic methods using such prodrug compositions. Preferably, the quinone compounds of the invention are napthoquinone compounds such as β-lapachone or β-lapachone analogs. The quinone prodrug compositions of the invention exhibit improved solubility, stability, bioavailability, and pharmacokinetic properties, as well as improved plasma half-life in vivo.
公开/授权文献
- EP1877097B1 AMINOACID CONJUGATES OF BETA-LAPACHONE FOR TUMOR TARGETING 公开/授权日：2012-06-20
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