发明公开
- 专利标题: NEW COMPOUNDS I
- 专利标题(中): 新化合物我
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申请号: EP06733400.3申请日: 2006-05-08
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公开(公告)号: EP1881950A1公开(公告)日: 2008-01-30
- 发明人: JONASSON, Catrin , MOLIN, Håkan , ROTTICCI, Didier
- 申请人: AstraZeneca AB
- 申请人地址: 151 85 Södertälje SE
- 专利权人: AstraZeneca AB
- 当前专利权人: AstraZeneca AB
- 当前专利权人地址: 151 85 Södertälje SE
- 代理机构: Wahlström, Stig Christer Gunnar
- 优先权: SE0501057 20050509
- 国际公布: WO2006121391 20061116
- 主分类号: C07C43/253
- IPC分类号: C07C43/253 ; A61K31/22 ; A61K31/275 ; A61K31/41 ; A61P29/00 ; C07C235/58 ; C07C235/84 ; C07C255/56 ; C07C257/04
摘要:
A compound of formula (I), or pharmaceutically acceptable salts thereof wherein X is selected from hydrogen, halo, -CN, -CON2, -CON(C1-6alkyl)H, -CON(C1-6alkyl)2 and heterocyclic groups; R1 is selected from C1-6alkyl and C3-6cycloalkyl; whereby Z is -OH, M is selected from C(O)- , -CH(ORa) , N(Ra) , and S(O)r-, wherein Ra is hydrogen or C1-6alkyl and r is 0, 1 or 2, R2 is selected from C1-6alkyl, C3-6cycloalkyl, heterocycloalkyl, aryl, alkylaryl, and heteroaryl, R2 is substituted with halo, -NO2, -CN, -OH, -CF3, -OCF3, -NH2, and/or -CONH2, when Y is -C1-6alkyl; or Z is -C1-6alkoxy, M is bond, R2 is selected from C1-6alkyl, C3-6cycloalkyl, heterocycloalkyl, aryl, alkylaryl, and heteroaryl, when Y is -C1-6alkoxy.
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