发明授权
- 专利标题: A NOVEL PROCESS FOR THE PREPARATION OF LERCANIDIPINE
- 专利标题(中): 新工艺用于生产乐卡地平
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申请号: EP05760546.1申请日: 2005-06-15
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公开(公告)号: EP1891009B1公开(公告)日: 2009-10-14
- 发明人: PARTHASARADHI REDDY, Bandi , RATHNAKAR REDDY, Kura Hetero Drugs Ltd.(R & D) , RAJI REDDY, Rapolu Hetero Drugs Ltd.(R & D) , MURALIDHARA REDDY, Dasari Hetero Drugs Ltd.(R & D) , SATISH KUMAR, Dandamudi, Hetero Drugs Limited (R & D)
- 申请人: Hetero Drugs Limited
- 申请人地址: Hetero House 8-3-166/7/1, Erragadda Hyderabad, Andhrapradesh. Hyderabad 500 018 IN
- 专利权人: Hetero Drugs Limited
- 当前专利权人: Hetero Drugs Limited
- 当前专利权人地址: Hetero House 8-3-166/7/1, Erragadda Hyderabad, Andhrapradesh. Hyderabad 500 018 IN
- 代理机构: Thomas, Simon
- 国际公布: WO2006134606 20061221
- 主分类号: C07D211/02
- IPC分类号: C07D211/02 ; C07D211/90
摘要:
The invention provides a novel process for the preparation of lercanidipine or a pharmaceutical acceptable salt using novel intermediates. Thus, 2,N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol is reacted with trimethylsilyl chloride in presence of triethyl amine in methylene chloride to give 2,N-dimethyl-2-(trimethylsilyloxy)-N-(3,3-diphenylpropyl)-1-propanamine, which is then reacted with 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl chloride for 2 hours and crystallized to obtain lercanidipine hydrochloride.
公开/授权文献
- EP1891009A1 A NOVEL PROCESS FOR THE PREPARATION OF LERCANIDIPINE 公开/授权日:2008-02-27
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