发明公开
EP1896473A1 1- ( 2-AMINO-3- (SUBSTITUTED ALKYL)-3H-BENZIMIDAZOIYLMETHYL) -3-SUBTITUTED-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES WITH ACTIVITY ON RESPIRATORY SYNCYTIAL VIRUS
有权
1 - [[2-氨基-3-（取代基亚烷基）-3H-苯并咪唑]甲基] -3-取代基-1,3-二氢吲哚并咪唑-2-酮ALS代谢酶抑制剂同系物
- 专利标题： 1- ( 2-AMINO-3- (SUBSTITUTED ALKYL)-3H-BENZIMIDAZOIYLMETHYL) -3-SUBTITUTED-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES WITH ACTIVITY ON RESPIRATORY SYNCYTIAL VIRUS
- 专利标题（中）： 1 - [[2-氨基-3-（取代基亚烷基）-3H-苯并咪唑]甲基] -3-取代基-1,3-二氢吲哚并咪唑-2-酮ALS代谢酶抑制剂同系物
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申请号： EP06763808.0申请日： 2006-06-20
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公开(公告)号： EP1896473A1公开(公告)日： 2008-03-12
- 发明人: BONFANTI, Jean-François , MULLER, Philippe , FORTIN, Jérôme, Michel, Claude , DOUBLET, Frédéric, Marc, Maurice
- 申请人： Tibotec Pharmaceuticals Ltd.
- 申请人地址： Eastgate Village Little Island, Co. Cork IE
- 专利权人： Tibotec Pharmaceuticals Ltd.
- 当前专利权人： Tibotec Pharmaceuticals Ltd.
- 当前专利权人地址： Eastgate Village Little Island, Co. Cork IE
- 代理机构： Wante, Dirk Paul Maria
- 优先权： EP05076438 20050620
- 国际公布： WO2006136561 20061228
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D401/14 ; A61K31/437 ; A61P11/00
摘要：
Inhibitors of RSV replication of formula (I) which can be represented by formula (I) the salts and stereochemically isomeric forms thereof, wherein R is a radical of formula (a) or (b); Q is hydrogen or C1-6alkyl optionally substituted with a heterocycle or Q is C1-6alkyl substituted with both a radical -OR4 and a heterocycle; Alk is C1-6alkanediyl; X is O or S; -a1=a2-a3=a4 - is -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH- or -CH=CH-CH=N-; R1 is Ar or a heterocycle; R2 is hydrogen, C1-6alkyl, substituted C1-6alkyl, C3-7cycloalkyl; R3 is hydrogen, C1-6alkyl, cyano, aminocarbonyl, polyhaloC1-6alkyl, C2-6alkenyl or C2-6alkynyl; R4 is hydrogen or C1-6alkyl; Ar is phenyl or substituted phenyl; Het is a heterocycle; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).
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