A process for producing a porous hollow fiber polyvinylidene fluoride resin membrane, comprises: blending a polyvinylidene fluoride resin with an organic liquid and an inorganic particulate material; heat melting the resulting blend at a temperature of 60°C or more above the melting point of the resin during the melt extrusion process; continuously extruding the molten blend in the form of a hollow fiber; and passing the resulting hollow fiber-shaped extrudate through the air between the hollow fiber spinning nozzle and a cooling bath, before taking up said extrudate. This process allows preparation of a porous hollow fiber polyvinylidene fluoride resin membrane despite having a large inside diameter yet still having excellent pressure resistance and high water flux, and which is therefore suitable especially for treatment of highly viscous liquids.