发明公开
EP1899324A2 BENZIMIDAZOLE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS
有权
Benzimidazolcarbonsäureamid化合物作为5-HT 4受体激动剂
- 专利标题： BENZIMIDAZOLE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS
- 专利标题（中）： Benzimidazolcarbonsäureamid化合物作为5-HT 4受体激动剂
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申请号： EP06760341.5申请日： 2006-05-24
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公开(公告)号： EP1899324A2公开(公告)日： 2008-03-19
- 发明人: MCKINNELL, Robert, Murray , GENDRON, Roland , JIANG, Lan , CHOI, Seok-ki , LONG, Daniel, D. , FATHEREE, Paul, R. , MARQUESS, Daniel , DALZIEL, Sean, M. , PHIZACKERLEY, Kirsten, M.
- 申请人： Theravance, Inc.
- 申请人地址： 901 Gateway Boulevard South San Francisco, CA 94080 US
- 专利权人： Theravance, Inc.
- 当前专利权人： Theravance, Inc.
- 当前专利权人地址： 901 Gateway Boulevard South San Francisco, CA 94080 US
- 代理机构： Scott, Susan Margaret
- 优先权： US684466P 20050525; US684478P 20050525; US748415P 20051208
- 国际公布： WO2006127815 20061130
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D405/14 ; C07D409/14 ; A61K31/4545 ; A61P1/00
摘要：
The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I) wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
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