- 专利标题： DODECYLSULFATE SALT OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR
- 专利标题（中）： 甜菊糖苷
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申请号： EP06836090.8申请日： 2006-07-21
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公开(公告)号： EP1909776A2公开(公告)日： 2008-04-16
- 发明人: ELLISON, Martha, E. , PERESYPKIN, Andrey, V. , WENSLOW, Robert, M.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Hussain, Deeba
- 优先权： US702232P 20050725
- 国际公布： WO2007035198 20070329
- 主分类号： A61K31/10
- IPC分类号： A61K31/10
摘要：
The dodecylsulfate salt of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro[l,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-l-(2,4,5-trifluorophenyl)butan-2-amine is a potent inhibitor of dipeptidyl peptidase-IV and is useful for the treatment of Type 2 diabetes. The invention also relates to a crystalline anhydrate of the dodecylsulfate salt as well as a process for its preparation, pharmaceutical compositions containing this novel form and methods of use for the treatment of Type 2 diabetes, hyperglycemia, insulin resistance, and obesity.
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