发明公开
EP1910352A1 HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
审中-公开
杂芳族化合物AS硬脂酰 - 辅酶A-Δ9去饱和酶的抑制剂
- 专利标题： HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
- 专利标题（中）： 杂芳族化合物AS硬脂酰 - 辅酶A-Δ9去饱和酶的抑制剂
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申请号： EP06761137.6申请日： 2006-07-18
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公开(公告)号： EP1910352A1公开(公告)日： 2008-04-16
- 发明人: BLACK, Cameron , DESCHENES, Denis , GAGNON, Marc , LACHANCE, Nicolas , LEBLANC, Yves , LEGER, Serge , LI, Chun, Sing , OBALLA, Renata, M.
- 申请人： Merck Frosst Canada Ltd.
- 申请人地址： 16711 Trans-Canada Highway Kirkland, Québec H9H 3L1 CA
- 专利权人： Merck Frosst Canada Ltd.
- 当前专利权人： Merck Frosst Canada Ltd.
- 当前专利权人地址： 16711 Trans-Canada Highway Kirkland, Québec H9H 3L1 CA
- 代理机构： Hussain, Deeba
- 优先权： US700798P 20050720; US738435P 20051121
- 国际公布： WO2007009236 20070125
- 主分类号： C07D417/14
- IPC分类号： C07D417/14 ; A61P3/06 ; A61K31/501 ; A61P3/10 ; C07D413/14
摘要：
Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and fatty liver disease.
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