发明公开
- 专利标题： NON-TOXIC BIOFILM INHIBITOR
- 专利标题（中）： 没有毒生物膜抑制剂
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申请号： EP06849801.3申请日： 2006-07-21
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公开(公告)号： EP1919494A2公开(公告)日： 2008-05-14
- 发明人: HODGES, Robert S. , IRVIN, Randall T. , GILTNER, Carmen , VAN SCHAIK, Erin
- 申请人： The Regents of the University of Colorado, A Body Corporate , University of Alberta
- 申请人地址： 4001 Discovery Drive, Suite 390 Boulder, CO 80303 US
- 专利权人： The Regents of the University of Colorado, A Body Corporate,University of Alberta
- 当前专利权人： The Regents of the University of Colorado, A Body Corporate,University of Alberta
- 当前专利权人地址： 4001 Discovery Drive, Suite 390 Boulder, CO 80303 US
- 代理机构： O'Connell, Maura
- 优先权： US701561P 20050722
- 国际公布： WO2007089272 20070809
- 主分类号： A61K38/16
- IPC分类号： A61K38/16
摘要：
The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.
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