发明公开
EP1931665A1 1-[[1-[(2-AMIN0-6-METHYL-4-PYRIDINYL)METHYL]-4-FLU0R0-4-PIPERIDINYL,]CARBONYL]-4-[2-(2-PYRIDINYL)-3H-IMIDAZ0[4, 5-B]PYRIDIN-3-YL]PIPERIDINE USEFUL AS HISTAMINE H3 ANTAGONIST
审中-公开
ALS HISTAMIN-H3-ANTAGONIST GEEIGNETES 1 - [[1 - [（2-氨基-6-甲基-4-吡啶基）甲基] -4-氟-4-哌啶基]羰基] -4- [2-（2-吡啶基） ）-3H-咪唑并[4,5-b]吡啶-3-基]哌啶
- 专利标题： 1-[[1-[(2-AMIN0-6-METHYL-4-PYRIDINYL)METHYL]-4-FLU0R0-4-PIPERIDINYL,]CARBONYL]-4-[2-(2-PYRIDINYL)-3H-IMIDAZ0[4, 5-B]PYRIDIN-3-YL]PIPERIDINE USEFUL AS HISTAMINE H3 ANTAGONIST
- 专利标题（中）： ALS HISTAMIN-H3-ANTAGONIST GEEIGNETES 1 - [[1 - [（2-氨基-6-甲基-4-吡啶基）甲基] -4-氟-4-哌啶基]羰基] -4- [2-（2-吡啶基） ）-3H-咪唑并[4,5-b]吡啶-3-基]哌啶
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申请号： EP06803837.1申请日： 2006-09-19
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公开(公告)号： EP1931665A1公开(公告)日： 2008-06-18
- 发明人: DE LERA RUIZ, Manuel , ASLANIAN, Robert, G. , BERLIN, Michael, Y. , MCCORMICK, Kevin, D. , CELLY, Chander, S.
- 申请人： Schering Corporation
- 申请人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 US
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 US
- 代理机构： HOFFMANN EITLE
- 优先权： US718673P 20050920
- 国际公布： WO2007035703 20070329
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61P37/08 ; A61P3/00
摘要：
The present invention discloses the compound of Formula I and pharmaceutically acceptable salts and solvates thereof. The invention also relates to pharmaceutical compositions comprising the Compound of Formula I and its use in treating obesity, metabolic syndrome, diabetes, hepatic lipidosis or nonalcoholic fatty liver disease. The invention also relates to the use of a combination of the Compound of Formula I with additional therapeutic agents for treating obesity, metabolic syndrome, diabetes, hepatic lipidosis or nonalcoholic fatty liver disease.
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