发明公开
- 专利标题： TYROSINE KINASE INHIBITORS
- 专利标题（中）： 酪氨酸激酶抑制剂
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申请号： EP06803333.1申请日： 2006-09-11
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公开(公告)号： EP1934200A1公开(公告)日： 2008-06-25
- 发明人: DINSMORE, Christopher, J. , GUERIN, David, J. , HANNEY, Barbara , KIM, Yuntae , SPENCER, Keith, L. , TORRENT, Maricel
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Hussain, Deeba
- 优先权： US717462P 20050915
- 国际公布： WO2007035309 20070329
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; A61K31/404 ; A61K31/416 ; A61K31/4192 ; A61P19/02 ; A61P35/00
摘要：
The present invention relates to pyridinyloxy- and pyrimidinyloxyindole derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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