发明公开
EP1934600A2 KINETIC BIOMARKER FOR QUANTIFICATION OF LYMPHOPROLIFERATION, CLONAL EXPANSION, RECRUITMENT AND TRAFFICKING IN LYMPHOID TISSUES AND OF THE IN VIVO ACTIONS OF ANTIGENS AND MODULATING AGENTS THEREON
审中-公开
KINETIC生物标志物的定量淋巴组织增生的，克隆扩增，招聘和贩卖淋巴和抗原，并应MODULATIONSAGENTIEN的体内影响
- 专利标题： KINETIC BIOMARKER FOR QUANTIFICATION OF LYMPHOPROLIFERATION, CLONAL EXPANSION, RECRUITMENT AND TRAFFICKING IN LYMPHOID TISSUES AND OF THE IN VIVO ACTIONS OF ANTIGENS AND MODULATING AGENTS THEREON
- 专利标题（中）： KINETIC生物标志物的定量淋巴组织增生的，克隆扩增，招聘和贩卖淋巴和抗原，并应MODULATIONSAGENTIEN的体内影响
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申请号： EP06814223.1申请日： 2006-09-06
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公开(公告)号： EP1934600A2公开(公告)日： 2008-06-25
- 发明人: HELLERSTEIN, Marc, K. , BUSCH, Robert
- 申请人： Kinemed, Inc.
- 申请人地址： 5980 Horton Street, Suite 470 Emeryville, CA 94608 US
- 专利权人： Kinemed, Inc.
- 当前专利权人： Kinemed, Inc.
- 当前专利权人地址： 5980 Horton Street, Suite 470 Emeryville, CA 94608 US
- 代理机构： Kiddle, Simon John
- 优先权： US714873P 20050906
- 国际公布： WO2007030523 20070315
- 主分类号： G01N33/50
- IPC分类号： G01N33/50
摘要：
The methods of the present invention allow for the measurement of proliferation, clonal expansion trafficking and/or recruitment of lymphocytes into lymphoid tissue in an in vivo setting. Proliferation, clonal expansion, recruitment and/or trafficking of lymphocytes are measured by using stable isotopes to label newly synthesized DNA, isolating the newly-labeled DNA, and quantifying enrichment of the isolated DNA with mass spectrometry or other appropriate techniques. Such methods are useful in screening candidate drugs for stimulatory or inhibitory effects on proliferation, clonal expansion, recruitment and/or trafficking of lymphocytes. The methods also allow for the discovery of therapeutic agents in disorders of immune regulation such as HIV infection and for optimizing vaccine efficacy.
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