发明公开
- 专利标题: DERIVATIVE HAVING PPAR AGONISTIC ACTIVITY
- 专利标题(中): DERIVAT MIT PPAR-AGONISTISCHERAKTIVITÄT
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申请号: EP06782968.9申请日: 2006-08-24
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公开(公告)号: EP1939189A1公开(公告)日: 2008-07-02
- 发明人: ITAI, Akiko , MUTO, Susumu , TOKUYAMA, Ryuko , FUKASAWA, Hiroshi , OHARA, Takafumi , KATO, Terukazu
- 申请人: SHIONOGI & CO., LTD. , Institute of Medicinal Molecular Design, Inc.
- 申请人地址: 1-8, Doshomachi 3-chome, Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 专利权人: SHIONOGI & CO., LTD.,Institute of Medicinal Molecular Design, Inc.
- 当前专利权人: SHIONOGI & CO., LTD.,Institute of Medicinal Molecular Design, Inc.
- 当前专利权人地址: 1-8, Doshomachi 3-chome, Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 代理机构: Vossius & Partner
- 优先权: JP2005246297 20050826; JP2006154607 20060602
- 国际公布: WO2007023882 20070301
- 主分类号: C07D277/82
- IPC分类号: C07D277/82 ; A61K31/4439 ; A61K31/445 ; A61K31/454 ; A61K31/496 ; A61K31/498 ; A61K31/551 ; A61P3/04 ; A61P3/06 ; A61P3/10 ; A61P9/10 ; A61P43/00 ; C07D211/22 ; C07D211/58 ; C07D241/04 ; C07D241/44 ; C07D401/04 ; C07D403/04 ; C07D413/14 ; C07D417/04 ; C07D417/12
摘要:
A compound of the formula (I):
a pharmaceutically acceptable salt or solvate thereof, wherein
Ring Q is optionally substituted monocyclic aryl, optionally substituted monocyclic heteroaryl, optionally substituted fused aryl or optionally substituted fused heteroaryl,
Y 1 is a bond or -NR 6 - or the like,
Ring A is optionally substituted nonaromatic heterocyclediyl,
a group of the formula: -Y 2 Z 1 - is a group of the formula:
or
R 7 are each independently hydrogen, optionally substituted lower alkyl or the like,
R 8 and R 9 are each independently hydrogen or optionally substituted lower alkyl,
n is an integer between 1 and 3,
Z 1 is a bond, -O-, -S- or -NR 9 -,
Ring B is optionally substituted aromatic carbocyclediyl or optionally substituted aromatic heterocyclediyl,
Y 3 is a bond, optionally substituted lower alkylene optionally intervened by -O-, optionally substituted lower alkenylene or the like, and
Z 2 is COOR 3 or the like.
a pharmaceutically acceptable salt or solvate thereof, wherein
Ring Q is optionally substituted monocyclic aryl, optionally substituted monocyclic heteroaryl, optionally substituted fused aryl or optionally substituted fused heteroaryl,
Y 1 is a bond or -NR 6 - or the like,
Ring A is optionally substituted nonaromatic heterocyclediyl,
a group of the formula: -Y 2 Z 1 - is a group of the formula:
or
R 7 are each independently hydrogen, optionally substituted lower alkyl or the like,
R 8 and R 9 are each independently hydrogen or optionally substituted lower alkyl,
n is an integer between 1 and 3,
Z 1 is a bond, -O-, -S- or -NR 9 -,
Ring B is optionally substituted aromatic carbocyclediyl or optionally substituted aromatic heterocyclediyl,
Y 3 is a bond, optionally substituted lower alkylene optionally intervened by -O-, optionally substituted lower alkenylene or the like, and
Z 2 is COOR 3 or the like.
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