发明公开
EP1945270A4 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR V LEIDEN MUTANT GENE
有权
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR HEMMUNG DER EXPRESSION VON FAKTOR V LEIDEN MUTATIONSGEN
- 专利标题： COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR V LEIDEN MUTANT GENE
- 专利标题（中）： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR HEMMUNG DER EXPRESSION VON FAKTOR V LEIDEN MUTATIONSGEN
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申请号： EP06837014申请日： 2006-11-07
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公开(公告)号： EP1945270A4公开(公告)日： 2009-10-21
- 发明人: VORNLOCHER HANS-PETER , MARAGANORE JOHN M
- 申请人： ALNYLAM PHARMACEUTICALS INC
- 专利权人： ALNYLAM PHARMACEUTICALS INC
- 当前专利权人： ALNYLAM PHARMACEUTICALS INC
- 优先权： US73575905 2005-11-09
- 主分类号： A61K31/713
- IPC分类号： A61K31/713 ; C12N15/113
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor V Leiden mutant gene (Factor V Leiden mutant gene), comprising an antisense strand having a nucleotide sequence which is less than 25 nucleotides in length and which is substantially complementary to at least a part of the Factor V Leiden mutant gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Factor V Leiden mutant gene using the pharmaceutical composition; and methods for inhibiting the expression of the Factor V Leiden mutant gene in a cell.
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