发明公开
EP1960363A2 QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF
有权
喹诺酮类PROLYLHYDROXYLASEHEMMENDER效应和组合物及其应用链接
- 专利标题： QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF
- 专利标题（中）： 喹诺酮类PROLYLHYDROXYLASEHEMMENDER效应和组合物及其应用链接
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申请号： EP06844992.5申请日： 2006-12-08
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公开(公告)号： EP1960363A2公开(公告)日： 2008-08-27
- 发明人: ALLEN, Jennifer R. , TEGLEY, Christopher M. , BISWAS, Kaustav , BURLI, Roland , MULLER, Kristine M. , FROHN, Michael J. , GOLDEN, Jennifer E. , MERCEDE, Stephanie J. , NEIRA, Susana C. , PETERKIN, Tanya A. N. , HUNGATE, Randall W. , KURZEJA, Robert , YU, Violeta , DAO, Jennifer
- 申请人： Amgen, Inc.
- 申请人地址： One Amgen Center Drive Thousand Oaks, CA 91320-1799 US
- 专利权人： Amgen, Inc.
- 当前专利权人： Amgen, Inc.
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, CA 91320-1799 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： US748577P 20051209; US785358P 20060324
- 国际公布： WO2007070359 20070621
- 主分类号： C07D215/22
- IPC分类号： C07D215/22
摘要：
This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
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