发明公开
- 专利标题: NEW COMPOUNDS
- 专利标题(中): 新化合物
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申请号: EP06831521.7申请日: 2006-12-19
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公开(公告)号: EP1963336A1公开(公告)日: 2008-09-03
- 发明人: NÓGRÁDI, Katalin , WÁGNER, Gábor , KESERÜ, György , BIELIK, Attila , GÁTI, Tamás , HÁDA, Viktor , KÓTI, János , GÁL, Krisztina , VASTAG, Mónika , BOBOK, Amrita, Ágnes
- 申请人: Richter Gedeon NYRT
- 申请人地址: Gyömröi út 19-21 1103 Budapest HU
- 专利权人: Richter Gedeon NYRT
- 当前专利权人: Richter Gedeon NYRT
- 当前专利权人地址: Gyömröi út 19-21 1103 Budapest HU
- 代理机构: HOFFMANN EITLE
- 优先权: HU0501166 20051220; HU0600919 20061218
- 国际公布: WO2007072094 20070628
- 主分类号: C07D495/04
- IPC分类号: C07D495/04 ; A61K31/4365 ; A61P25/00
摘要:
The present invention relates to new mGluRl and mGluR5 receptor subtype preferring ligands of formula (I) wherein X represents a group selected from CO, SO, SO2; Y represents a group selected from 0, OCH2, (CH2)n, NH, NHCH2; n is an integer of 0 to 2; R1 is an optionally substituted alkyl, cycloalkyl, phenyl, biphenyl, heterocyclyl; R2 is an optionally substituted phenyl, heterocyclyl or NR3R4 group wherein R3 and R4 are independently selected from the group of hydrogen, alkyl, or R3 and R4 together with the N atom to which they are attached can form an optionally substituted C5-7 heterocyclyl group, containing one or more heteroatom(s) selected from the group of N, O, S, and/or tautomers and/or salts and/or hydrates and/or solvates thereof, to the processes for producing the same, to pharmaceutical compositions containing the same and to their use in therapy and/or prevention of pathological conditions which require the modulation of mGluRl and mGluR5 receptors such as neurological disorders, psychiatric disorders, acute and chronic pain, neuromuscular dysfunctions of the lower urinary tract and gastrointestinal disorders.
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