发明公开
- 专利标题： Quinazoline derivatives as kinase inhibitors
- 专利标题（中）： Quinazolinderivate als Kinasehemmer
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申请号： EP08075237.1申请日： 2001-08-17
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公开(公告)号： EP1964839A3公开(公告)日： 2008-11-05
- 发明人: Pandey, Anjali , Scarborough, Robert, M. , Matsuno, Kenji , Ichimura, Michio , Nomoto, Yuji , Ide, Shinichi , Tsukuda, Eiji , Irie, Junko , Oda, Shoji
- 申请人： MILLENNIUM PHARMACEUTICALS, INC. , KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址： 256 East Grand Avenue South San Francisco, CA 94080 US
- 专利权人： MILLENNIUM PHARMACEUTICALS, INC.,KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： MILLENNIUM PHARMACEUTICALS, INC.,KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址： 256 East Grand Avenue South San Francisco, CA 94080 US
- 代理机构： Wombwell, Francis
- 优先权： US226122P 20000818
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07D239/94 ; C07D401/12 ; A61P35/00 ; A61K31/517
摘要：
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
公开/授权文献
- EP1964839A2 Quinazoline derivatives as kinase inhibitors 公开/授权日：2008-09-03
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