发明公开
EP1971609A1 THIENOPYRIDINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
审中-公开
噻吩并吡啶衍生物作为代谢型谷氨酸受体调节剂的
- 专利标题: THIENOPYRIDINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
- 专利标题(中): 噻吩并吡啶衍生物作为代谢型谷氨酸受体调节剂的
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申请号: EP06831518.3申请日: 2006-12-19
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公开(公告)号: EP1971609A1公开(公告)日: 2008-09-24
- 发明人: NÓGRÁDI, Katalin , WÁGNER, Gábor , KESERÜ, György , BIELIK, Attila , GÁTI, Tamás , HÁDA, Viktor , KÓTI, János , GÁL, Krisztina , VASTAG, Mónika , BOBOK, Amrita, Ágnes
- 申请人: Richter Gedeon NYRT
- 申请人地址: Gyömröi út 19-21 1103 Budapest HU
- 专利权人: Richter Gedeon NYRT
- 当前专利权人: Richter Gedeon NYRT
- 当前专利权人地址: Gyömröi út 19-21 1103 Budapest HU
- 代理机构: HOFFMANN EITLE
- 优先权: HU0501168 20051220
- 国际公布: WO2007072090 20070628
- 主分类号: C07D495/04
- IPC分类号: C07D495/04 ; A61K31/4365 ; A61P25/28
摘要:
The present invention relates to new mGluRl and niGluR5 receptor subtype preferring ligands of formula (I): wherein X represents a group selected from (CH2)n, CH=CH, NH, N(CH3), NHCH2, N(CH3)CH2, O, OCH2, CH2COO, NHCH2COO; n is an integer of O to 2; Y represents a subtituent selected from H, CH3, F, Cl, Br; Z is H or CH3; R is alkyl, cycloalkyl, an optionally substituted phenyl or an optionally substituted heteroaryl, and/or geometric isomers and/or salts and/or hydrates and/or solvates thereof, to the processes for producing the same, to pharmaceutical compositions containing the same and to their use in therapy and/or prevention of pathological conditions which require the modulation of mGluRl mGluR5 receptors such as neurological disorders, psychiatric disorders, acute and chronic pain and neuromuscular dysfunctions of the lower urinary tract.
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