发明公开
EP1973895A1 PROCESS FOR ISOLATION OF DESIRED ISOMERS OF NEBIVOLOL INTERMEDIATES
审中-公开
式分离方法通缉种异构体奈必洛尔中间体的
- 专利标题： PROCESS FOR ISOLATION OF DESIRED ISOMERS OF NEBIVOLOL INTERMEDIATES
- 专利标题（中）： 式分离方法通缉种异构体奈必洛尔中间体的
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申请号： EP06711356.3申请日： 2006-01-18
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公开(公告)号： EP1973895A1公开(公告)日： 2008-10-01
- 发明人: PARTHASARADHI REDDY, Bandi , RATHNAKAR REDDY, Kura , RAJI REDDY, Rapolu , MURALIDHARA REDDY, Dasari , SRINIVAS REDDY, Itiyala
- 申请人： Hetero Drugs Limited
- 申请人地址： Hetero House 8-3-166/7/1, Erragadda Hyderabad, Andhrapradesh. Hyderabad 500 018 IN
- 专利权人： Hetero Drugs Limited
- 当前专利权人： Hetero Drugs Limited
- 当前专利权人地址： Hetero House 8-3-166/7/1, Erragadda Hyderabad, Andhrapradesh. Hyderabad 500 018 IN
- 代理机构： Green, Mark Charles
- 国际公布： WO2007083318 20070726
- 主分类号： C07D311/58
- IPC分类号： C07D311/58
摘要：
The present invention relates to a simple and commercially viable process for separation of desired isomers of nebivolol intermediates from a mixture containing undesired isomers of nebivolol intermediates. Thus, (+)-[2R*[1S*,5S*(S*)]]+[2R*[1S*,5R*(R*)]]-α,α'- [phenylmethyliminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] is dissolved in diisopropyl ether at reflux temperature and cooled to below 30°C to obtain the desired(+)-[2R*[1S*,5S*(S*)]]-alfa,alfa'-[phenylmethyliminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H- 1-benzopyran-2-methanol].
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