A portable power- supply device in accordance with the present invention comprises at least one Zinc-Air battery module (2) composed of at least one battery unit and a power transmission interface (3). In an embodiment, the power transmission interface can be selected from a charging connector, a charging socket or a charging cable (3) with a linking connector (31). The portable power supply device (1) can be connected to a portable electronic device through the power transmission interface, and can be applied to be the main power or the backup charging power for the portable electronic device. In an embodiment, the battery unit can be a primary Zinc-Air battery, rechargeable Zinc-Air battery, Zinc-Air battery with replaceable zinc plate, or Zinc-Air battery with replaceable zinc gel, and supply the voltage from 0.8V to 24V for well power charging to the portable electronic device. The power transmission interface is coupled to at least one pair of conductors of the Zinc-Air battery module, and for transmitting electric current generated by the Zinc-Air battery module. The Zinc-Air battery module and the battery unit are simultaneously made of at least one flexible material through integrated molding. The module (2) is housed in a plastic member (1) composed of a top cover (11) and bottom cover (12). The top cover (11) has air vents (13) for allowing passage of air to an air cathode.