发明公开
EP1981493A1 ACAT INHIBITORS AND THEIR USE IN THE PREVENTION OR TREATMENT OF FIBROSIS
审中-公开
ACAT抑制剂及它们在预防或纤维化的治疗
- 专利标题： ACAT INHIBITORS AND THEIR USE IN THE PREVENTION OR TREATMENT OF FIBROSIS
- 专利标题（中）： ACAT抑制剂及它们在预防或纤维化的治疗
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申请号： EP07845502.9申请日： 2007-11-13
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公开(公告)号： EP1981493A1公开(公告)日： 2008-10-22
- 发明人: HEKIMI, Siegfried , HIHI, Abdelmadjid K. , BRANICKY, Robyn S. , JIA, Xihua
- 申请人： Chronogen Inc. , Sosei Co. Ltd.
- 申请人地址： 2901 Rachel E., Suite 22 Montréal, Quebec H1W 4A4 CA
- 专利权人： Chronogen Inc.,Sosei Co. Ltd.
- 当前专利权人： Chronogen Inc.,Sosei Co. Ltd.
- 当前专利权人地址： 2901 Rachel E., Suite 22 Montréal, Quebec H1W 4A4 CA
- 代理机构： Thomas, Dean
- 优先权： US858349P 20061113; US935753P 20070829
- 国际公布： WO2008058383 20080522
- 主分类号： A61K31/357
- IPC分类号： A61K31/357 ; A61K45/06 ; A61P43/00
摘要：
The present invention relates to the use of ACAT inhibitors, {e.g. F-1394, Avasimibe (CI-1011), Pactimibe (CS505), Efluimibe (F12511), Eldacimibe, NTE 122, AS-183, KW-3033, E5324, FY087, FCE27677, CI-976, K-604, TEI6522, Octimibate, FR179254, and S 58-035, or mixtures thereof), compositions comprising the same, and methods for preventing or treating fibrosis, for preventing or reducing collagen deposition in a tissue, and in the prevention and reduction of excessive fibrous connective tissue
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