发明公开
EP1981494A1 STABILIZED PHARMACEUTICAL COMPOSITIONS COMPRISING AN HMG-COA REDUCTASE INHIBITOR
审中-公开
与HMG-CoA还原酶抑制剂的稳定药物组合物
- 专利标题： STABILIZED PHARMACEUTICAL COMPOSITIONS COMPRISING AN HMG-COA REDUCTASE INHIBITOR
- 专利标题（中）： 与HMG-CoA还原酶抑制剂的稳定药物组合物
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申请号： EP06705097.1申请日： 2006-02-02
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公开(公告)号： EP1981494A1公开(公告)日： 2008-10-22
- 发明人: LAXMINARAYAN, Joshi
- 申请人： Orbus Pharma Inc.
- 申请人地址： 20 Konrad Crescent Markham, ON L3R 8T4 CA
- 专利权人： Orbus Pharma Inc.
- 当前专利权人： Orbus Pharma Inc.
- 当前专利权人地址： 20 Konrad Crescent Markham, ON L3R 8T4 CA
- 代理机构： Vogel, Andreas
- 优先权： US315986 20051223
- 国际公布： WO2007071012 20070628
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K9/20 ; A61K47/40 ; A61K9/16 ; A61P3/06
摘要：
The present invention is a new stable drug composition particularly suitable for use as an antihypercholesterolaemic or antihyperlipidaemic agent. The present invention is specifically a drug composition comprising a pharmaceutical, a complexing agent and a surfactant, and a method for manufacturing same. When applied to unstable drugs with low solubility and poor bioavailability, like HMG-CoA reductase inhibitors and especially atorvastatin calcium amorphous form, the resulting drug composition is more stable and is characterized by an improved dissolution profile.
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