发明公开
- 专利标题: USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS
- 专利标题(中): 4-咪唑衍生物用于CNS疾病中的用途
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申请号: EP07703939.4申请日: 2007-01-17
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公开(公告)号: EP1981880A2公开(公告)日: 2008-10-22
- 发明人: GALLEY, Guido , GROEBKE ZBINDEN, Katrin , HOENER, Marius , NORCROSS, Roger , STALDER, Henri
- 申请人: F.HOFFMANN-LA ROCHE AG
- 申请人地址: Grenzacherstrasse 124 4070 Basel CH
- 专利权人: F.HOFFMANN-LA ROCHE AG
- 当前专利权人: F.HOFFMANN-LA ROCHE AG
- 当前专利权人地址: Grenzacherstrasse 124 4070 Basel CH
- 代理机构: Poppe, Regina
- 优先权: EP06100938 20060127
- 国际公布: WO2007085556 20070802
- 主分类号: C07D405/06
- IPC分类号: C07D405/06 ; C07D233/54 ; A61K31/4174 ; A61K31/4178 ; A61P25/00
摘要:
The present invention relates to the use of compounds of formula (I) wherein R is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, phenyl, S-phenyl or O-phenyl, which are optionally substituted by lower alkoxy or halogen, or is benzyloxy, C(O)O-lower alkyl, cycloalkyl, or is lower alkyl or lower alkoxy substituted by halogen; Ar is aryl or heteroaryl, selected from the group consisting of phenyl, naphthyl, pyridinyl, benzofuranyl, dihydrobenzofuranyl or pyrazole; R1/R1' are independently from each other hydrogen, hydroxy, lower alkyl, lower alkoxy or are phenyl or benzyl, which are optionally substituted by halogen; R2 is hydrogen or lower alkyl; n is 1, 2, 3 or 4; and to their pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers and tautomeric forms for the preparation of medicaments for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
公开/授权文献
- EP1981880B1 USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS 公开/授权日:2010-02-24
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