发明公开
- 专利标题: CARBOHYDRATE-MIMETIC PEPTIDES AND USE THEREOF IN PHARMACEUTICAL FORMULATIONS
- 专利标题(中): 化学药剂中的维生素D
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申请号: EP06828471.0申请日: 2006-12-28
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公开(公告)号: EP1982994A2公开(公告)日: 2008-10-22
- 发明人: MENÉNDEZ MEDINA, Tamara , CRUZ LEAL, Yoelys , REYES ACOSTA, Osvaldo , GARAY PÉREZ, Hilda, Elisa , GUILLÉN NIETO, Gerardo, Enrique , COIZEAU RODRÍGUEZ, Edelgis , SANTIAGO VISPO, Nelson, Francisco , CHINEA SANTIAGO, Glay
- 申请人: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
- 申请人地址: Departamento de Patentes Ave. 31 entre 158 y 190, Cubanacan, Playa Ciudad de La Habana 10600 CU
- 专利权人: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
- 当前专利权人: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
- 当前专利权人地址: Departamento de Patentes Ave. 31 entre 158 y 190, Cubanacan, Playa Ciudad de La Habana 10600 CU
- 代理机构: Hatzmann, Martin
- 优先权: CU2832005 20051229
- 国际公布: WO2007073706 20070705
- 主分类号: C07K14/22
- IPC分类号: C07K14/22 ; A61K38/16 ; G01N33/68
摘要:
The present invention is related with the pharmaceutical industry and the biotechnology, specifically with vaccine antigens applied against bacterial, viral, cancerous or another origin diseases. Development of pharmaceuticals formulations able to protect or to increase the protective spectrum of already developed vaccines and to extend it against several pathogens, using as target for the immune response, carbohydrates composed of repeated units of (α 2-8) linked N-replaced neuraminic acid. Several peptides were isolated and identified as molecular mimetics of the capsular polysaccharide form serogroup B of Neisseria meningitidis, which is composed of repeated units of (α 2-8) linked N-acetyl neuraminic acid. The immunogenicity of peptides was evaluated in animal biomodels, demonstrating their value as antigens able to induce the production of antibodies able of specifically recognize the bacterium N. meningitidis from serogroup B and of showing bactericidal activity against the same one. The resulting formulations of are applicable in the pharmaceutical industry as vaccine formulations for human use.
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