发明公开
- 专利标题： CHEMICAL COMPOUNDS
- 专利标题（中）： 化学化合物
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申请号： EP07705135.7申请日： 2007-02-07
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公开(公告)号： EP1984330A1公开(公告)日： 2008-10-29
- 发明人: ARNOULD, Jean-Claude , DELOUVRIE, Benedicte , KETTLE, Jason, Grant
- 申请人： AstraZeneca AB
- 申请人地址： 151 85 Södertälje SE
- 专利权人： AstraZeneca AB
- 当前专利权人： AstraZeneca AB
- 当前专利权人地址： 151 85 Södertälje SE
- 代理机构： Nelson, Michael Andrew
- 优先权： EP06300120 20060209
- 国际公布： WO2007091046 20070816
- 主分类号： C07D205/04
- IPC分类号： C07D205/04 ; C07D207/08 ; C07D207/12 ; C07D207/48 ; C07D211/46 ; C07D211/96 ; C07D401/06 ; C07D403/06 ; C07D409/06 ; C07D413/06 ; A61K31/166 ; A61K31/18 ; A61K31/33 ; C07C233/87 ; C07C311/32
摘要：
The present invention relates to compounds that inhibit a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to compounds that inhibit a5b1, and also that exhibit appropriate selectivity profile(s) against other integrins.
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