发明公开
- 专利标题： BIFUNCTIONAL HISTONE DEACETYLASE INHIBITORS
- 专利标题（中）： 双功能的组蛋白去乙酰化酶抑制剂
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申请号： EP07872648.6申请日： 2007-02-14
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公开(公告)号： EP1991247A1公开(公告)日： 2008-11-19
- 发明人: BRADNER, James, Elliot , MAZITSCHEK, Ralph , TANG, Weiping , SCHREIBER, Stuart, L.
- 申请人： The President and Fellows of Harvard College , Dana-Farber Cancer Institute
- 申请人地址： 17 Quincy Avenue Cambridge, MA 02139 US
- 专利权人： The President and Fellows of Harvard College,Dana-Farber Cancer Institute
- 当前专利权人： The President and Fellows of Harvard College,Dana-Farber Cancer Institute
- 当前专利权人地址： 17 Quincy Avenue Cambridge, MA 02139 US
- 代理机构： Crooks, Elizabeth Caroline
- 优先权： US773510P 20060214
- 国际公布： WO2008091349 20080731
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K31/44 ; A61K31/19
摘要：
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
公开/授权文献
- EP1991247B1 BIFUNCTIONAL HISTONE DEACETYLASE INHIBITORS 公开/授权日：2015-10-14
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