发明公开
EP1992688A1 METHOD OF CONSTRUCTING RECOMBINANT PROTEOLIPOSOME FOR DIAGNOSTIC USE
有权
VERFAHREN ZUR KONSTRUKTION EINES REKOMBINANTEN PROTEOLIPOSOMS ZUR DIAGNOSTISCHEN VERWENDUNG
- 专利标题： METHOD OF CONSTRUCTING RECOMBINANT PROTEOLIPOSOME FOR DIAGNOSTIC USE
- 专利标题（中）： VERFAHREN ZUR KONSTRUKTION EINES REKOMBINANTEN PROTEOLIPOSOMS ZUR DIAGNOSTISCHEN VERWENDUNG
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申请号： EP07714229.7申请日： 2007-02-15
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公开(公告)号： EP1992688A1公开(公告)日： 2008-11-19
- 发明人: YOSHIMURA, Tetsuro , TSUMOTO, Kanta , IMAMURA, Kouji , MORINO, Kazuhiko , KOBAYASHI, Jun
- 申请人： Mie University , Medical & Biological Laboratories Co., Ltd.
- 申请人地址： 1577, Kurimamachiya-cho Tsu-shi Mie 514-8507 JP
- 专利权人： Mie University,Medical & Biological Laboratories Co., Ltd.
- 当前专利权人： Mie University,Medical & Biological Laboratories Co., Ltd.
- 当前专利权人地址： 1577, Kurimamachiya-cho Tsu-shi Mie 514-8507 JP
- 代理机构： von Kreisler Selting Werner
- 优先权： JP2006038076 20060215
- 国际公布： WO2007094395 20070823
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; C12M1/00 ; C12N15/09 ; G01N33/549 ; G01N33/564 ; G01N33/58 ; G01N33/68
摘要：
[PROBLEMS] To provide a method for preparation of recombinant proteoliposomes suitable for diagnostic applications, a detection plate coated with the recombinant proteoliposomes, a detection kit and so on.
[PROBLEM-SOLVING MEANS] Recombinant proteoliposomes are prepared by fusion of budded virus particles of a recombinant baculovirus, expressing a target membrane receptor (such as human thyroid-stimulating hormone receptor, acetylcholine receptor, insulin receptor, β1 adrenalin receptor, asialoglycoprotein receptor, etc., each participating in an autoantibody-related disease), with liposomes. Compared with the recombinant baculoviruses, these proteoliposomes have an improved ability to bind to an autoantibody and makes it possible to produce easily a kit for its detection.
[PROBLEM-SOLVING MEANS] Recombinant proteoliposomes are prepared by fusion of budded virus particles of a recombinant baculovirus, expressing a target membrane receptor (such as human thyroid-stimulating hormone receptor, acetylcholine receptor, insulin receptor, β1 adrenalin receptor, asialoglycoprotein receptor, etc., each participating in an autoantibody-related disease), with liposomes. Compared with the recombinant baculoviruses, these proteoliposomes have an improved ability to bind to an autoantibody and makes it possible to produce easily a kit for its detection.
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