发明公开
EP1996570A1 PROCEDE DE PREPARATION DE DÉRIVÉS [2-(2,3-DIHYDRO-BENZOFURAN- OU BENZOFURAN-7-YLOXY)-ETHYL]-(3-CYCLOPENTEN-1-YL-BENZYL)-AMINES ET INTERMEDIAIRE DE SYNTHESE
审中-公开
PROCESS FOR [2-（2,3-二氢苯并呋喃或苯并呋喃-7-基氧基）乙基]的制备 - （3 - 环戊-1-基 - 苄基）胺衍生物及其合成中间体
- 专利标题： PROCEDE DE PREPARATION DE DÉRIVÉS [2-(2,3-DIHYDRO-BENZOFURAN- OU BENZOFURAN-7-YLOXY)-ETHYL]-(3-CYCLOPENTEN-1-YL-BENZYL)-AMINES ET INTERMEDIAIRE DE SYNTHESE
- 专利标题（英）： Process for preparing [2-(2,3-dihydrobenzofuran- or benzofuran-7-yloxy)ethyl]-(3-cyclopent-1-ylbenzyl)amine derivatives and synthesis intermediate
- 专利标题（中）： PROCESS FOR [2-（2,3-二氢苯并呋喃或苯并呋喃-7-基氧基）乙基]的制备 - （3 - 环戊-1-基 - 苄基）胺衍生物及其合成中间体
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申请号： EP07731168.6申请日： 2007-03-08
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公开(公告)号： EP1996570A1公开(公告)日： 2008-12-03
- 发明人: VACHER, Bernard , CUISIAT, Stéphane , ROQUES, Nicolas
- 申请人： Pierre Fabre Médicament S.A.
- 申请人地址： 45, Place Abel Gance 92100 Boulogne FR
- 专利权人： Pierre Fabre Médicament S.A.
- 当前专利权人： Pierre Fabre Médicament S.A.
- 当前专利权人地址： 45, Place Abel Gance 92100 Boulogne FR
- 代理机构： Rousseau, Pierrick Edouard
- 优先权： FR0602194 20060314
- 国际公布： WO2007104872 20070920
- 主分类号： C07D307/86
- IPC分类号： C07D307/86 ; C07D307/94 ; C07D317/20 ; C07C47/548
摘要：
ABSTRACT. PROCESS FOR PREPARING [2-(2,3-DIHYDROBENZOFURAN- OR BENZOFURAN-7-YLOXY)ETHYL]-(3-CYCLOPENT-1-YLBENZYL)AMINE DERIVATIVES AND SYNTHESIS INTERMEDIATE The invention relates to a process for preparing compounds of general formula (see “abstract” paper version) in which: - (a) is a single or double bond; - W is a CH, CH2, CHCH3, CCH3 or C(CH3)2 group or a C(CH2)2 group (i.e. a carbon atom bearing two methylene groups linked to one another so as to form a spirocyclopropane unit), with the proviso, however, that, when (a) is a double bond, then W is exclusively a CH or CCH3 group and that, when (a) is a single bond, then W is exclusively a CH2, CHCH3, C(CH3)2 or C(CH2)2 group.
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