发明公开
EP1996574A1 QUINOLINE AND ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS
审中-公开
喹啉和异喹啉衍生物作为磷酸二酯酶10抑制剂
- 专利标题： QUINOLINE AND ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS
- 专利标题（中）： 喹啉和异喹啉衍生物作为磷酸二酯酶10抑制剂
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申请号： EP07752718.2申请日： 2007-03-08
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公开(公告)号： EP1996574A1公开(公告)日： 2008-12-03
- 发明人: LIU, Ruiping , ARRINGTON, Mark, P. , HOPPER, Allen, T. , CONTICELLO, Richard, D. , HITCHCOCK, Stephen, A.
- 申请人： Amgen Inc. , Memory Pharmaceuticals Corporation
- 申请人地址： One Amgen Center Drive M/S 28-2-C Thousand Oaks CA 91320-1799 US
- 专利权人： Amgen Inc.,Memory Pharmaceuticals Corporation
- 当前专利权人： Amgen Inc.,Memory Pharmaceuticals Corporation
- 当前专利权人地址： One Amgen Center Drive M/S 28-2-C Thousand Oaks CA 91320-1799 US
- 代理机构： Ritter, Thomas Kurt
- 优先权： US780611P 20060308
- 国际公布： WO2007103554 20070913
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D413/04 ; C07D417/04 ; A61K31/47 ; A61P25/00 ; A61P25/18
摘要：
The present invention is directed to certain quinoline and isoquinoline compounds that are PDElO inhibitors, pharmaceutical compositions containing such compounds and processes for preparing such compounds. The invention is also directed to methods of treating diseases mediated by PDElO enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
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