发明公开
EP1996706A2 USE OF APOPTOSIS-SPECIFIC EIF-5A SIRNA TO DOWN REGULATE EXPRESSION OF PROINFLAMMATORY CYTOKINES TO TREAT SEPSIS
审中-公开
凋亡特异性EIF-5A的siRNA下调表达促炎细胞因子对于脓毒病的治疗中
- 专利标题： USE OF APOPTOSIS-SPECIFIC EIF-5A SIRNA TO DOWN REGULATE EXPRESSION OF PROINFLAMMATORY CYTOKINES TO TREAT SEPSIS
- 专利标题（中）： 凋亡特异性EIF-5A的siRNA下调表达促炎细胞因子对于脓毒病的治疗中
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申请号： EP07758920.8申请日： 2007-03-20
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公开(公告)号： EP1996706A2公开(公告)日： 2008-12-03
- 发明人: THOMPSON, John, E.
- 申请人： Senesco Technologies, Inc.
- 申请人地址： 303 George St., Ste 420 New Brunswick, NJ 08901 US
- 专利权人： Senesco Technologies, Inc.
- 当前专利权人： Senesco Technologies, Inc.
- 当前专利权人地址： 303 George St., Ste 420 New Brunswick, NJ 08901 US
- 代理机构： Vossius & Partner
- 优先权： US783413P 20060320; US798333P 20060508
- 国际公布： WO2007109674 20070927
- 主分类号： C12N15/11
- IPC分类号： C12N15/11
摘要：
The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for down regulating pro-inflammatory cytokines in a mammal by administering siRNA against eIF-5A1 to the mammal to treat/prevent sepsis and/or hemorrhagic shock.
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