发明公开
- 专利标题： Albumin fusion proteins
- 专利标题（中）： 白蛋白融合蛋白
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申请号： EP08075724.8申请日： 2002-12-23
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公开(公告)号： EP1997829A1公开(公告)日： 2008-12-03
- 发明人: Ballance, David James , Turner, Andrew John , Rosen, Craig A. , Haseltine, William A. , Ruben, Steven M.
- 申请人： HUMAN GENOME SCIENCES, INC. , Novozymes Biopharma UK Limited
- 申请人地址： 9410 Key West Avenue Rockville, MD 20850 US
- 专利权人： HUMAN GENOME SCIENCES, INC.,Novozymes Biopharma UK Limited
- 当前专利权人： HUMAN GENOME SCIENCES, INC.,Novozymes Biopharma UK Limited
- 当前专利权人地址： 9410 Key West Avenue Rockville, MD 20850 US
- 代理机构： Bassett, Richard Simon
- 优先权： US341811P 20011221; US350358P 20020124; US351360P 20020128; US359370P 20020226; US360000P 20020228; US367500P 20020327; US370227P 20020408; US378950P 20020510; US382617P 20020524; US383123P 20020528; US385708P 20020605; US394625P 20020710; US398008P 20020724; US402131P 20020809; US402708P 20020813; US411426P 20020918; US411355P 20020918; US414984P 20021002; US417611P 20021011; US420246P 20021023; US423623P 20021105
- 主分类号： C07K14/765
- IPC分类号： C07K14/765 ; C12N15/62
摘要：
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
The fusion protein may comprise a hybrid (human serum albumin)/Kex2 leader sequence followed by a mature albumin fused to the N-terminus of mature interferon alpha-2b.
The fusion protein may comprise a hybrid (human serum albumin)/Kex2 leader sequence followed by a mature albumin fused to the N-terminus of mature interferon alpha-2b.
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