发明公开
- 专利标题： COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE JC VIRUS
- 专利标题（中）： 抑制JC病毒基因表达的组合物和方法
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申请号： EP07761452.7申请日： 2007-04-27
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公开(公告)号： EP2013222A2公开(公告)日： 2009-01-14
- 发明人: TAN, Pamela , SAH, Dinah , BRAMLAGE, Birgit
- 申请人： Alnylam Pharmaceuticals Inc.
- 申请人地址： 300 Third Street, Third Floor Cambridge MA 02142 US
- 专利权人： Alnylam Pharmaceuticals Inc.
- 当前专利权人： Alnylam Pharmaceuticals Inc.
- 当前专利权人地址： 300 Third Street, Third Floor Cambridge MA 02142 US
- 代理机构： Wachenfeld, Joachim
- 优先权： US795765P 20060428
- 国际公布： WO2007127919 20071108
- 主分类号： C07H21/04
- IPC分类号： C07H21/04
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.
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