发明公开
EP2014644A1 A process for the resolution of racemic verapamil
审中-公开
Verfahren zurLösungvon racemischen维拉帕米
- 专利标题： A process for the resolution of racemic verapamil
- 专利标题（中）： Verfahren zurLösungvon racemischen维拉帕米
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申请号： EP08157735.5申请日： 2008-06-06
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公开(公告)号： EP2014644A1公开(公告)日： 2009-01-14
- 发明人: Bertolotti, Chiara , Lussana, Massimiliano , Pizzatti, Enrica , Vigano', Enrico , Landonio, Ernesto
- 申请人： Cosma S.p.A.
- 申请人地址： Via Colleoni, 15/17 24040 Ciserano IT
- 专利权人： Cosma S.p.A.
- 当前专利权人： Cosma S.p.A.
- 当前专利权人地址： Via Colleoni, 15/17 24040 Ciserano IT
- 代理机构： Cattaneo, Elisabetta
- 优先权： ITMI20071160 20070607
- 主分类号： C07C253/32
- IPC分类号： C07C253/32 ; C07C255/43
摘要：
A new process is described for the resolution of racemic verapamil, which allows the desired enantiomer to be obtained in high yields and with high enantiomeric purity. The process uses optically active 2,3-bis[(2-fluorobenzoyl)oxy]butanedioic acid as the resolving agent, and a water/dimethylformamide or water/acetonitrile or water/methanol mixture, as the reaction solvent.
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