发明授权
EP2016102B1 CHIMERIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE
无效
CHIMERA T细胞受体及相关材料和使用方法
- 专利标题： CHIMERIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE
- 专利标题（中）： CHIMERA T细胞受体及相关材料和使用方法
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申请号： EP07797329.5申请日： 2007-05-03
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公开(公告)号： EP2016102B1公开(公告)日： 2012-03-21
- 发明人: MORGAN, Richard A. , COHEN, Cyrille J. , ROSENBERG, Steven A.
- 申请人： Government of the United States of America, Represented by the Secretary, Department of Health and Human Services
- 申请人地址： Office of Technology Transfer 6011 Executive Boulevard, Suite 325 Rockville, Maryland 20852 US
- 专利权人： Government of the United States of America, Represented by the Secretary, Department of Health and Human Services
- 当前专利权人： Government of the United States of America, Represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： Office of Technology Transfer 6011 Executive Boulevard, Suite 325 Rockville, Maryland 20852 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser
- 优先权： US796853P 20060503
- 国际公布： WO2007131092 20071115
- 主分类号： C07K19/00
- IPC分类号： C07K19/00 ; C07K14/725
摘要：
The invention provides a chimeric T cell receptor (TCR) comprising a variable region of a human TCR and a constant region comprising at least an extracellular domain of a constant region of a non-human TCR, as well as functional variants thereof. The invention also provides polypeptides and proteins related to the inventive TCRs, as well as nucleic acids encoding the TCRs, polypeptides, or proteins, recombinant expression vectors, and host cells. Further provided are pharmaceutical compositions related to the inventive TCRs and methods of preventing or treating a disease, e.g., an infectious disease, cancer, in a host, methods of detecting a diseased cell in a host, and methods of improving the biological activity of a TCR.
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