发明授权
EP2022788B1 NOVEL CRYSTAL OF 3-[5-[4-(CYCLOPENTYLOXY)-2- HYDROXYBENZOYL]-2-[(3-HYDROXY-1,2-BENZISOXAZOL-6-YL)METHOXY]PHENYL]PROPIONIC ACID
有权
新的晶体形式的3- [5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-羟基-1,2-苯并异唑-6-基）甲氧基]苯基]丙酸
- 专利标题： NOVEL CRYSTAL OF 3-[5-[4-(CYCLOPENTYLOXY)-2- HYDROXYBENZOYL]-2-[(3-HYDROXY-1,2-BENZISOXAZOL-6-YL)METHOXY]PHENYL]PROPIONIC ACID
- 专利标题（中）： 新的晶体形式的3- [5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-羟基-1,2-苯并异唑-6-基）甲氧基]苯基]丙酸
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申请号： EP07744104.6申请日： 2007-05-25
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公开(公告)号： EP2022788B1公开(公告)日： 2010-09-01
- 发明人: YONEZAWA, Kenji , KOTSUBO, Hironori , BABA, Yasutaka , TADA, Yukie
- 申请人： TOYAMA CHEMICAL CO., LTD.
- 申请人地址： 2-5, 3-chome, Nishishinjuku, Shinjuku-ku Tokyo 160-0023 JP
- 专利权人： TOYAMA CHEMICAL CO., LTD.
- 当前专利权人： TOYAMA CHEMICAL CO., LTD.
- 当前专利权人地址： 2-5, 3-chome, Nishishinjuku, Shinjuku-ku Tokyo 160-0023 JP
- 代理机构： Hartz, Nikolai
- 优先权： JP2006146220 20060526
- 国际公布： WO2007138996 20071206
- 主分类号： C07D261/12
- IPC分类号： C07D261/12 ; A61K31/42 ; A61P19/02
摘要：
Disclosed is a crystal of 3-[5-[4-(cyclopentyloxy)-2- hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6- yl)methoxy]phenyl]propionic acid having refraction angles of 14.0, 16.0, 23.3, 23.7 and 26.3˚ as measured in terms of 2ϑ in powder X-ray diffraction pattern. Also disclosed is a crystal of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3- hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionic acid having refraction angles of 14.6, 23.1, 24.7, 25.6 and 26.0˚ as measured in terms of 2ϑ in powder X-ray diffraction pattern. These crystals have small specific volumes, are hardly charged electrically, can be handled easily, and are useful as excellent active ingredients for anti-rheumatic drugs.
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