发明公开
EP2024352A1 GLUCOPYRANOSYL-SUBSTITUTED BENZONITRILE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE
有权
吡喃葡萄糖基取代苯甲腈衍生物,这样的化合物的药物组合物,它们的使用及其制造方法
- 专利标题: GLUCOPYRANOSYL-SUBSTITUTED BENZONITRILE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE
- 专利标题(中): 吡喃葡萄糖基取代苯甲腈衍生物,这样的化合物的药物组合物,它们的使用及其制造方法
-
申请号: EP07728702.7申请日: 2007-05-02
-
公开(公告)号: EP2024352A1公开(公告)日: 2009-02-18
- 发明人: ECKHARDT, Matthias , HIMMELSBACH, Frank , EICKELMANN, Peter , SAUER, Achim , THOMAS, Leo
- 申请人: Boehringer Ingelheim International GmbH , Boehringer Ingelheim Pharma GmbH & Co. KG
- 申请人地址: Binger Strasse 173 55216 Ingelheim am Rhein DE
- 专利权人: Boehringer Ingelheim International GmbH,Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人: Boehringer Ingelheim International GmbH,Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人地址: Binger Strasse 173 55216 Ingelheim am Rhein DE
- 代理机构: Hammann, Heinz
- 优先权: EP06113412 20060503; EP06124833 20061127; PCT/EP2007/051411 20070214
- 国际公布: WO2007128749 20071115
- 主分类号: C07D309/10
- IPC分类号: C07D309/10 ; A61K31/351
摘要:
Glucopyranosyl- substituted, benzonitrile derivatives defined according to formula I, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof . The compounds according to the invention are suitable for the treatment of metabolic disorders. formula (I), wherein R3 denotes hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, propyl, \ isopropyl, butyl, sec-butyl, iso-butyl, tert-butyl, 3-methyl-but-1-yl, cyclopropyl, \ cyclobutyl, cyclopentyl, cyclohexyl, 1-hydroxy-cyclopropyl, 1-hydroxy-cyclobutyl, 1- hydroxy-cyclopentyl, 1 -hydroxy-cyclohexyl, difluoromethyl, trifluoromethyl, pentafluoroethyl,_2-hydroxyl-ethyl, hydroxymethyl, 3-hydroxy-propyl, 2-hydroxy-2- methyl-prop-1-yl, 3-hydroxy-3-methyl-but-1-yl, 1-hydroxy-1 -methyl-ethyl, 2,2,2- trifluoro-1-hydroxy-1 -methyl-ethyl, 2,2,2-trifluoro-i-hydroxy-i-trifluoromethyl-ethyl, 2- methoxy-ethyl, 2-ethoxy-ethyl, hydroxy, difiuoromethyloxy, trifluoromethyloxy, 2- methyloxy-ethyloxy, methylsulfanyl, methylsulfinyl, methlysulfonyl, ethylsulfinyl, ethylsulfonyl, trimethylsilyl or cyano,
公开/授权文献
信息查询