发明公开
EP2024352A1 GLUCOPYRANOSYL-SUBSTITUTED BENZONITRILE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE 有权
吡喃葡萄糖基取代苯甲腈衍生物,这样的化合物的药物组合物,它们的使用及其制造方法

GLUCOPYRANOSYL-SUBSTITUTED BENZONITRILE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE
摘要:
Glucopyranosyl- substituted, benzonitrile derivatives defined according to formula I, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof . The compounds according to the invention are suitable for the treatment of metabolic disorders. formula (I), wherein R3 denotes hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, propyl, \ isopropyl, butyl, sec-butyl, iso-butyl, tert-butyl, 3-methyl-but-1-yl, cyclopropyl, \ cyclobutyl, cyclopentyl, cyclohexyl, 1-hydroxy-cyclopropyl, 1-hydroxy-cyclobutyl, 1- hydroxy-cyclopentyl, 1 -hydroxy-cyclohexyl, difluoromethyl, trifluoromethyl, pentafluoroethyl,_2-hydroxyl-ethyl, hydroxymethyl, 3-hydroxy-propyl, 2-hydroxy-2- methyl-prop-1-yl, 3-hydroxy-3-methyl-but-1-yl, 1-hydroxy-1 -methyl-ethyl, 2,2,2- trifluoro-1-hydroxy-1 -methyl-ethyl, 2,2,2-trifluoro-i-hydroxy-i-trifluoromethyl-ethyl, 2- methoxy-ethyl, 2-ethoxy-ethyl, hydroxy, difiuoromethyloxy, trifluoromethyloxy, 2- methyloxy-ethyloxy, methylsulfanyl, methylsulfinyl, methlysulfonyl, ethylsulfinyl, ethylsulfonyl, trimethylsilyl or cyano,
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