发明公开
- 专利标题： HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS
- 专利标题（中）： 杂环ASPARTYL蛋白酶抑制剂
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申请号： EP07795971.6申请日： 2007-06-07
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公开(公告)号： EP2032542A2公开(公告)日： 2009-03-11
- 发明人: WU, Yusheng , ISERLOH, Ulrich , CUMMING, Jared , LIU, Xiaoxiang , MAZZOLA, Robert, D. , SUN, Zhong-Yue , HUANG, Ying , STAMFORD, Andrew , MCKITTRICK, Brian , ZHU, Zhaoning
- 申请人： Schering Corporation
- 申请人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 US
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 US
- 代理机构： Mathys & Squire LLP
- 优先权： US812744P 20060612
- 国际公布： WO2007146225 20071221
- 主分类号： C07D239/20
- IPC分类号： C07D239/20 ; C07D401/04 ; C07D401/10 ; C07D403/04 ; C07D405/04 ; C07D409/14 ; C07D411/04 ; C07D417/14 ; C07D495/20 ; A61K31/513 ; A61P25/28
摘要：
Disclosed are compounds of formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, U, W, X, R1, R2, R6, R7, R30 and R31 are as described above in the specification. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
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