发明公开
- 专利标题: C-PHENYL 1-THIOGLUCITOL COMPOUND
- 专利标题(中): C-苯基1-硫代胡萝卜醇化合物
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申请号: EP07767824.1申请日: 2007-06-28
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公开(公告)号: EP2036901A1公开(公告)日: 2009-03-18
- 发明人: KAKINUMA, Hiroyuki , OI, Takahiro , KOBASHI, Yohei , HASHIMOTO, Yuko , TAKAHASHI, Hitomi
- 申请人: TAISHO PHARMACEUTICAL CO., LTD
- 申请人地址: 24-1 Takata 3-chome, Toshima-ku Tokyo 170-8633 JP
- 专利权人: TAISHO PHARMACEUTICAL CO., LTD
- 当前专利权人: TAISHO PHARMACEUTICAL CO., LTD
- 当前专利权人地址: 24-1 Takata 3-chome, Toshima-ku Tokyo 170-8633 JP
- 代理机构: HOFFMANN EITLE
- 优先权: JP2006179971 20060629
- 国际公布: WO2008001864 20080103
- 主分类号: C07D335/02
- IPC分类号: C07D335/02 ; A61K31/382 ; A61P3/10 ; A61P43/00
摘要:
C-phenyl 1-thioglucitol compounds of the following formula (I) or pharmaceutically acceptable salts thereof or hydrates thereof:
[wherein
X represents a hydrogen atom or a C 1-6 alkyl group,
Y represents a C 1-6 alkylene group or -O-(CH 2 )n- (wherein n represents an integer of 1 to 5), and
Z represents -CONHR A or -NHCONHR B (provided that when Z represents -NHCONHR B , n is not 1),
wherein
R A represents a C 1-6 alkyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxyl group and -CONH 2 , and
R B represents a hydrogen atom or a C 1-6 alkyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxyl group and -CONH 2 ] are useful as prophylactic or therapeutic agents for diabetes, because of their suppressive effect on sugar (e.g., glucose) absorption through inhibition of SGLT1 activity, or alternatively, because of their suppressive effect on sugar (e.g., glucose) absorption and excretory effect on urinary sugars through inhibition of both SGLT1 and SGLT2 activities.
[wherein
X represents a hydrogen atom or a C 1-6 alkyl group,
Y represents a C 1-6 alkylene group or -O-(CH 2 )n- (wherein n represents an integer of 1 to 5), and
Z represents -CONHR A or -NHCONHR B (provided that when Z represents -NHCONHR B , n is not 1),
wherein
R A represents a C 1-6 alkyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxyl group and -CONH 2 , and
R B represents a hydrogen atom or a C 1-6 alkyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxyl group and -CONH 2 ] are useful as prophylactic or therapeutic agents for diabetes, because of their suppressive effect on sugar (e.g., glucose) absorption through inhibition of SGLT1 activity, or alternatively, because of their suppressive effect on sugar (e.g., glucose) absorption and excretory effect on urinary sugars through inhibition of both SGLT1 and SGLT2 activities.
公开/授权文献
- EP2036901B1 C-PHENYL 1-THIOGLUCITOL COMPOUND 公开/授权日:2013-05-01
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