发明公开
EP2036901A1 C-PHENYL 1-THIOGLUCITOL COMPOUND 有权
C-苯基1-硫代胡萝卜醇化合物

C-PHENYL 1-THIOGLUCITOL COMPOUND
摘要:
C-phenyl 1-thioglucitol compounds of the following formula (I) or pharmaceutically acceptable salts thereof or hydrates thereof:

[wherein
X represents a hydrogen atom or a C 1-6 alkyl group,
Y represents a C 1-6 alkylene group or -O-(CH 2 )n- (wherein n represents an integer of 1 to 5), and
Z represents -CONHR A or -NHCONHR B (provided that when Z represents -NHCONHR B , n is not 1),
wherein
R A represents a C 1-6 alkyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxyl group and -CONH 2 , and
R B represents a hydrogen atom or a C 1-6 alkyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxyl group and -CONH 2 ] are useful as prophylactic or therapeutic agents for diabetes, because of their suppressive effect on sugar (e.g., glucose) absorption through inhibition of SGLT1 activity, or alternatively, because of their suppressive effect on sugar (e.g., glucose) absorption and excretory effect on urinary sugars through inhibition of both SGLT1 and SGLT2 activities.
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